Does PectaSol cause the "Grapefruit Effect"?Updated a month ago

Since PectaSol is derived from citrus fruit, there may be an unnecessary concern about the

"grapefruit effect" Bergamottin is a natural furanocoumarin found principally in grapefruit

juice. It is also found in the bergamot oil, where it was first isolated and from which its name is

derived. To a lesser extent, bergamottin is also present in the essential oils of other citrus fruits

such as grapefruit and Seville oranges. PectaSol is highly purified 100% Pectin that is not derived

from grapefruit or Seville oranges. Along with the chemically related compound 6Ő,7Ő-

dihydroxybergamottin, it is believed to be responsible for the grapefruit juice effect. The

consumption of the juice affects the metabolism of a variety of pharmaceutical drugs. They are

inhibitors of some isoforms of the cytochrome P450 enzyme, particularly CYP3A4. This prevents

the oxidative metabolism of certain drugs by the enzyme, resulting in an elevated drug

concentration in the bloodstream. These compounds responsible for the "grapefruit effect"

have never been detected in the PectaSol preparation. Please feel confident that PectaSol does

not contain any detectable amount of the non-water-soluble components